Mescaline
3,4,5-Trimethoxyphenethylamine
Classic PsychedelicsNaturalClassic Psychedelic (Phenethylamine)
Duration
8-14 hours
Onset
1-3 hours
Peak
3-6 hours
Mescaline is a naturally occurring psychedelic alkaloid found in several cacti species, most notably peyote and San Pedro. It has been used for thousands of years in religious and healing ceremonies by indigenous peoples of the Americas.
⚠️ Safety Information
⚠️ Contraindications
Do not use if any of the following apply to you.
- •History of psychotic disorders
- •Severe mental health conditions
- •Heart conditions or high blood pressure
- •Pregnancy and breastfeeding
- •Use with certain medications (MAOIs, some antidepressants)
Effects
Physical
- •Initial nausea and possible vomiting
- •Increased energy and physical awareness
- •Enhanced tactile sensations
- •Mild increases in heart rate and blood pressure
- •Possible sweating or temperature changes
- •Generally gentle on the body compared to other psychedelics
Psychological
- •Enhanced empathy and emotional openness
- •Deep introspective insights
- •Sense of connection with nature and others
- •Spiritual or mystical experiences
- •Increased appreciation for beauty
- •Emotional healing and processing
Visual
- •Enhanced colors and visual acuity
- •Geometric patterns and fractals (less intense than LSD)
- •Nature appearing more vivid and alive
- •Possible morphing of surfaces
- •Light and shadow play enhancement
- •Generally less visually intense than other psychedelics
Therapeutic Potential
✓Treatment for depression and anxiety (research stage)
✓Addiction treatment, especially alcohol use disorder
✓PTSD and trauma healing
✓Enhanced creativity and artistic expression
✓Spiritual growth and development
✓Increased environmental consciousness
Legal Status
Schedule I in most countries, religious exemptions exist
Related Compounds
This is education, not medical advice. Always consult a healthcare professional before making decisions about substance use. Never use illegal substances.