Compounds/Ketamine

Ketamine

Ketamine Hydrochloride

DissociativesSyntheticDissociative Anesthetic (NMDA receptor antagonist)

Duration

45-90 minutes (intramuscular), 1-2 hours (oral)

Onset

2-5 minutes (IV), 5-15 minutes (IM), 15-30 minutes (oral)

Peak

10-30 minutes (IV/IM), 30-60 minutes (oral)

Ketamine is a dissociative anesthetic that has gained recognition as a breakthrough treatment for depression. Originally developed for medical anesthesia, it's now used both therapeutically for mental health conditions and recreationally for its unique consciousness-altering effects.

⚠️ Safety Information

⚠️ Contraindications

Do not use if any of the following apply to you.

  • •Severe cardiovascular disease or uncontrolled hypertension
  • •History of psychotic disorders
  • •Pregnancy and breastfeeding
  • •Active substance use disorders (relative contraindication)
  • •Severe kidney or liver disease

Effects

Physical

  • •Profound motor impairment and loss of coordination
  • •Numbness and loss of physical sensation
  • •Increased heart rate and blood pressure
  • •Nausea and vomiting (especially at higher doses)
  • •Muscle rigidity or relaxation
  • •Potential respiratory depression at high doses

Psychological

  • •Dissociation from body and environment
  • •Ego dissolution and loss of identity
  • •Out-of-body experiences
  • •Emotional detachment and numbness
  • •Altered perception of time and space
  • •Possible antidepressant effects lasting days to weeks

Visual

  • •Visual distortions and tunnel vision
  • •Geometric patterns and fractals
  • •Environmental morphing and warping
  • •Possible complete visual replacement at high doses
  • •Enhanced colors and visual depth

Therapeutic Potential

✓Rapid-acting depression treatment (FDA approved)
✓Treatment-resistant depression relief
✓Suicidal ideation reduction
✓PTSD and trauma therapy support
✓Chronic pain management
✓Possible addiction treatment applications

Legal Status

Schedule III (controlled but legal for medical use)

Related Compounds

Salvia Divinorum

5-30 minutes (smoked), 1-3 hours (chewed)

PCP

4-8 hours (effects can persist longer)

3-MeO-PCP

4-8 hours

Nitrous Oxide

30 seconds - 5 minutes

This is education, not medical advice. Always consult a healthcare professional before making decisions about substance use. Never use illegal substances.

Education and harm reduction only. This is not medical advice. Always consult a healthcare professional. Never use illegal substances.